synthetic lethality | UCD Cancer Data Lab https://cancerdata.ucd.ie/tag/synthetic-lethality/ synthetic lethality Wowchemy (https://wowchemy.com)en-usWed, 28 May 2025 15:19:22 +0000 https://cancerdata.ucd.ie/media/sharing.png synthetic lethality https://cancerdata.ucd.ie/tag/synthetic-lethality/ Proteomic compensation by paralogs preserves protein interaction networks after gene loss in cancer https://cancerdata.ucd.ie/publication/venkatesh-2025/ Wed, 28 May 2025 15:19:22 +0000 https://cancerdata.ucd.ie/publication/venkatesh-2025/ Exploiting Cancer Synthetic Lethality in Cancer---Lessons Learnt from PARP Inhibitors https://cancerdata.ucd.ie/publication/pettitt-2023-parp/ Sat, 18 Nov 2023 00:00:00 +0000 https://cancerdata.ucd.ie/publication/pettitt-2023-parp/ Targeting synthetic lethal paralogs in cancer https://cancerdata.ucd.ie/publication/ryan-2023-targeting/ Mon, 06 Mar 2023 00:00:00 +0000 https://cancerdata.ucd.ie/publication/ryan-2023-targeting/ Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines https://cancerdata.ucd.ie/publication/de-2021-comprehensive/ Wed, 15 Dec 2021 00:00:00 +0000 https://cancerdata.ucd.ie/publication/de-2021-comprehensive/ Cross-species identification of PIP5K1-, splicing-and ubiquitin-related pathways as potential targets for RB1-deficient cells https://cancerdata.ucd.ie/publication/parkhitko-2021-cross/ Tue, 16 Feb 2021 00:00:00 +0000 https://cancerdata.ucd.ie/publication/parkhitko-2021-cross/ Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions https://cancerdata.ucd.ie/publication/lord-2020-integrative/ Thu, 28 May 2020 00:00:00 +0000 https://cancerdata.ucd.ie/publication/lord-2020-integrative/ Cells lacking the RB1 tumor suppressor gene are hyperdependent on Aurora B kinase for survival https://cancerdata.ucd.ie/publication/oser-2019-cells/ Tue, 01 Jan 2019 00:00:00 +0000 https://cancerdata.ucd.ie/publication/oser-2019-cells/ Paralog buffering contributes to the variable essentiality of genes in cancer cell lines https://cancerdata.ucd.ie/publication/de-2019-paralog/ Tue, 01 Jan 2019 00:00:00 +0000 https://cancerdata.ucd.ie/publication/de-2019-paralog/ Synthetic Lethality and Cancer – Penetrance as the Major Barrier https://cancerdata.ucd.ie/publication/ryan-2018-synthetic/ Sat, 15 Sep 2018 00:00:00 +0000 https://cancerdata.ucd.ie/publication/ryan-2018-synthetic/ E-cadherin/ROS1 inhibitor synthetic lethality in breast cancer https://cancerdata.ucd.ie/publication/bajrami-2018-cadherin/ Sun, 01 Apr 2018 00:00:00 +0000 https://cancerdata.ucd.ie/publication/bajrami-2018-cadherin/ Identifying genetic dependencies in cancer by analyzing siRNA screens in tumor cell line panels https://cancerdata.ucd.ie/publication/campbell-2018-identifying/ Mon, 01 Jan 2018 00:00:00 +0000 https://cancerdata.ucd.ie/publication/campbell-2018-identifying/ CancerGD: a resource for identifying and interpreting genetic dependencies in cancer https://cancerdata.ucd.ie/publication/bridgett-2017-cancergd/ Wed, 26 Jul 2017 00:00:00 +0000 https://cancerdata.ucd.ie/publication/bridgett-2017-cancergd/ Large-scale profiling of kinase dependencies in cancer cell lines https://cancerdata.ucd.ie/publication/campbell-2016-large/ Thu, 03 Mar 2016 00:00:00 +0000 https://cancerdata.ucd.ie/publication/campbell-2016-large/